Regulation of signaling receptor activity

Across TCGA patient cohorts, RNA activity of the Regulation of signaling receptor activity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SHROOM4_S299, NUFIP2_S608, and SYNPO_S289, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of signaling receptor activity activity versus SHROOM4_S299 in LSCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SHROOM4_S299 →	+0.564	+0.586	<.001	<.001	3	3
LSCC	NUFIP2_S608 →	-0.787	-0.724	<.001	<.001	3	3
LSCC	SYNPO_S289 →	+1.609	+1.489	<.001	<.001	3	3
LSCC	REPS2_S550 →	-2.174	-1.239	.002	.003	3	2
OV	ARVCF_S345 →	-0.724	-0.703	.001	<.001	3	2
LSCC	USP24_S1285 →	+0.509	+0.664	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010469 vs SHROOM4_S299 — LSCC

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