Regulation of signaling receptor activity

Across TCGA cell cohorts, RNA activity of the Regulation of signaling receptor activity pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPRC5A, ADGRF1, and KRT19, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of signaling receptor activity activity versus GPRC5A in STOMACH (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GPRC5A →	+4.909	+1.369	.001	.005	3	12
URINARY_TRACT	ADGRF1 →	+4.055	+1.435	.003	.004	3	7
KIDNEY	KRT19 →	+5.568	+1.997	.005	<.001	3	7
KIDNEY	C6orf132 →	+2.095	+1.427	<.001	<.001	2	7
STOMACH	TRIM45 →	-1.529	-1.082	<.001	.005	3	5
STOMACH	DIXDC1 →	-1.383	-1.327	.003	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010469 vs GPRC5A — STOMACH

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