Mesenchymal cell proliferation

Across TCGA patient cohorts, RNA activity of the Mesenchymal cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS7, DCHS1, and TIMP3, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesenchymal cell proliferation activity versus ADAMTS7 in UCS (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	ADAMTS7 →	+1.696	+0.091	<.001	<.001	3	31
UCS	DCHS1 →	+2.031	+0.110	<.001	<.001	3	30
SCLC	TIMP3 →	+1.594	+0.065	.001	.002	3	29
TGCT	HSPG2 →	+2.043	+0.099	<.001	<.001	3	29
UCS	ZEB1 →	+1.935	+0.109	<.001	<.001	3	29
TGCT	CACHD1 →	+2.846	+0.118	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010463 vs ADAMTS7 — UCS

Explore this scatter interactively →