Mesenchymal cell proliferation

Across TCGA patient cohorts, RNA activity of the Mesenchymal cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JAM3, SLIT3, and RECK, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesenchymal cell proliferation activity versus JAM3 in UCEC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JAM3 →	+0.768	+0.950	<.001	<.001	3	8
LUAD	SLIT3 →	+0.878	+0.741	.001	.001	3	8
UCEC	RECK →	+0.856	+0.986	<.001	<.001	3	7
CCRCC	RHOJ →	+0.992	+0.691	<.001	.001	3	7
LSCC	LRRC32 →	+0.808	+0.811	<.001	.002	3	7
CCRCC	DCLK2 →	+0.759	+0.901	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010463 vs JAM3 — UCEC

Explore this scatter interactively →