Positive regulation of heart rate

Across TCGA patient cohorts, RNA activity of the Positive regulation of heart rate pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GASK1B, JCAD, and HEPH, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of heart rate activity versus GASK1B in LSCC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GASK1B →	+0.603	+0.057	<.001	<.001	3	7
UCEC	JCAD →	+0.492	+0.053	.002	.006	3	7
LSCC	HEPH →	+0.576	+0.068	<.001	<.001	3	7
OV	LUZP1 →	+0.393	+0.036	<.001	.002	3	7
LSCC	SAP30BP_S113 →	-0.458	-0.060	<.001	<.001	3	6
CCRCC	SMTN →	+0.447	+0.043	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010460 vs GASK1B — LSCC

Explore this scatter interactively →