Positive regulation of heart rate

Across TCGA cell cohorts, RNA activity of the Positive regulation of heart rate pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN1, FRMD6, and THBS1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of heart rate activity versus PTPN1 in LUNG_NSCLC_LUAD (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PTPN1 →	+0.956	+0.261	<.001	<.001	3	8
BONE	FRMD6 →	+3.352	+0.318	<.001	.006	3	7
BONE	THBS1 →	+5.449	+0.355	.002	.006	2	7
OESOPHAGUS	SDC4 →	+2.554	+0.250	.001	.004	3	6
BLOOD_Lymphoma	CHST14 →	+0.991	+0.198	<.001	.003	3	6
BONE	AFMID →	-1.027	-0.448	.003	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010460 vs PTPN1 — LUNG_NSCLC_LUAD

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