Negative regulation of heart rate

Across TCGA patient cohorts, RNA activity of the Negative regulation of heart rate pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM22_S384, MAP1B_T1949, and RAB31, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of heart rate activity versus TRIM22_S384 in LSCC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRIM22_S384 →	+0.897	+0.056	<.001	.006	3	4
PDAC	MAP1B_T1949 →	-0.320	-0.052	<.001	<.001	3	4
PDAC	RAB31 →	+0.427	+0.041	.001	.003	3	4
GBM	SUPT6H →	-0.322	-0.098	<.001	<.001	3	4
LSCC	ZNF462_S2172 →	-0.809	-0.079	<.001	<.001	3	4
LUAD	EHBP1_S1058 →	+0.426	+0.033	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010459 vs TRIM22_S384 — LSCC

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