Exit from mitosis

Across TCGA patient cohorts, RNA activity of the Exit from mitosis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP162, ZNF680, and FBXO5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Exit from mitosis activity versus CEP162 in LUAD (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CEP162 →	+0.389	+0.145	.003	.008	3	6
GBM	ZNF680 →	+0.438	+0.179	.003	.003	3	5
BRCA	FBXO5 →	+0.608	+0.299	<.001	<.001	3	5
HNSC	NSL1 →	+0.577	+0.556	.002	.001	3	5
BRCA	RAD51AP1 →	+0.799	+0.319	<.001	<.001	3	5
LSCC	SMAD4 →	+0.546	+0.478	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010458 vs CEP162 — LUAD

Explore this scatter interactively →