Exit from mitosis

Across TCGA cell cohorts, RNA activity of the Exit from mitosis pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIAA1958, HNRNPCL1, and RINL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIAA1958 grouped by Exit from mitosis-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	KIAA1958 →	+1.101	+0.343	.002	<.001	3	4
BONE	HNRNPCL1 →	+0.157	+0.388	.009	.004	3	3
LUNG_SCLC	RINL →	+2.022	+0.279	.006	.008	2	4
LUNG_NSCLC_LUSC	KLK6 →	-3.498	-0.405	<.001	.002	3	3
OESOPHAGUS	SIVA1 →	-1.040	-0.340	<.001	.001	3	3
LUNG_NSCLC_LUAD	CDKN2D →	-1.155	-0.430	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIAA1958 by Exit from mitosis activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →