Exit from mitosis

Across TCGA cell cohorts, RNA activity of the Exit from mitosis pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF444, ZYX, and PDIA6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Exit from mitosis activity versus ZNF444 in KIDNEY (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ZNF444 →	+0.845	+1.160	.007	.007	3	5
BLOOD_Leukemia	ZYX →	-2.458	-1.174	.002	<.001	3	4
LUNG_SCLC	PDIA6 →	-0.630	-0.829	.005	.003	3	4
BLOOD_Leukemia	RFC2 →	+0.581	+0.836	.005	.007	3	4
BREAST	COMTD1 →	+1.312	+0.721	<.001	.004	3	4
KIDNEY	PDE9A →	+2.142	+0.960	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010458 vs ZNF444 — KIDNEY

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