Centriole-centriole cohesion

Across TCGA patient cohorts, RNA activity of the Centriole-centriole cohesion pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHF8, ZFYVE26, and CEP128, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Centriole-centriole cohesion activity versus PHF8 in DLBC (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	PHF8 →	+1.366	+0.055	<.001	<.001	3	34
DLBC	ZFYVE26 →	+0.853	+0.049	<.001	<.001	3	34
THYM	CEP128 →	+1.341	+0.042	<.001	<.001	3	33
DLBC	SMCHD1 →	+1.323	+0.047	<.001	.001	3	33
DLBC	CEP76 →	+1.160	+0.066	<.001	<.001	3	33
DLBC	CCP110 →	+1.292	+0.058	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010457 vs PHF8 — DLBC

Explore this scatter interactively →