Centriole-centriole cohesion

Across TCGA patient cohorts, RNA activity of the Centriole-centriole cohesion pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPE, WDR93, and CCNE1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Centriole-centriole cohesion activity versus CENPE in UCEC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPE →	-0.809	-0.697	.003	.001	3	4
BRCA	WDR93 →	+0.693	+0.697	.001	.002	3	4
OV	CCNE1 →	-1.191	-0.699	<.001	.001	3	3
UCEC	DLGAP5 →	-0.951	-0.572	.009	.006	3	3
OV	CEP55 →	-0.801	-0.675	.005	.006	3	3
BRCA	ZNF385B →	+1.296	+0.564	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010457 vs CENPE — UCEC

Explore this scatter interactively →