Centriole-centriole cohesion

Across TCGA cell cohorts, RNA activity of the Centriole-centriole cohesion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF2AK4, IL15RA, and P3H1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF2AK4 grouped by Centriole-centriole cohesion-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EIF2AK4 →	+0.601	+0.242	.006	.003	3	5
BLOOD_Leukemia	IL15RA →	+1.617	+0.253	<.001	<.001	3	5
BREAST	P3H1 →	+1.348	+0.281	.002	.001	3	5
BREAST	SH3RF2 →	+1.301	+0.212	<.001	<.001	3	5
BLOOD_Leukemia	DSTN →	+1.292	+0.306	.001	.002	3	4
BLOOD_Leukemia	MCFD2 →	+1.026	+0.225	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF2AK4 by Centriole-centriole cohesion activity — BLOOD_Leukemia

Explore this box plot interactively →