Positive regulation of cell fate commitment

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP6D1, HSPB1, and PSME1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP6D1 grouped by Positive regulation of cell fate commitment-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MAP6D1 →	+0.502	+0.347	.001	.001	3	4
LARGE_INTESTINE	HSPB1 →	-1.686	-0.416	<.001	.008	3	4
OESOPHAGUS	PSME1 →	-0.973	-0.269	.001	.003	3	4
LIVER	GPX7 →	-2.366	-0.537	<.001	<.001	3	4
LUNG_NSCLC_LUAD	DNAH5 →	-0.726	-0.715	.001	.002	3	4
BONE	LAMA1 →	+2.540	+0.313	.007	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP6D1 by Positive regulation of cell fate commitment activity — BLOOD_Myeloma

Explore this box plot interactively →