Positive regulation of cell fate commitment

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRPF18, ATG12, and ADAM9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell fate commitment activity versus PRPF18 in PANCREAS (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PRPF18 →	-0.781	-0.151	.001	.005	3	4
OESOPHAGUS	ATG12 →	-0.989	-0.119	.007	.007	2	4
PANCREAS	ADAM9 →	-1.368	-0.153	.002	.005	3	3
OESOPHAGUS	UGP2 →	-0.702	-0.153	.003	<.001	3	3
LUNG_NSCLC_LUAD	HYLS1 →	-0.577	-0.353	.009	.007	3	3
OESOPHAGUS	TIMP1 →	-1.948	-0.204	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010455 vs PRPF18 — PANCREAS

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