Negative regulation of cell fate commitment

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRMD6, RCN3, and AGFG2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell fate commitment activity versus FRMD6 in LUAD (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FRMD6 →	+0.601	+0.639	<.001	.001	3	5
OV	RCN3 →	+1.016	+0.685	.001	.002	2	5
LUAD	AGFG2 →	-0.326	-0.590	.001	<.001	3	4
LUAD	SLC2A1 →	+1.184	+0.716	<.001	<.001	3	4
UCEC	S100A8 →	+2.062	+0.558	<.001	.001	3	4
LUAD	JAKMIP1 →	-0.155	-0.577	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010454 vs FRMD6 — LUAD

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