Negative regulation of cell fate commitment

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS1, EMP3, and FOSL1, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell fate commitment activity versus LGALS1 in LUNG_SCLC (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LGALS1 →	+6.463	+1.205	<.001	<.001	3	18
URINARY_TRACT	EMP3 →	+3.567	+0.283	<.001	<.001	3	14
CNS	FOSL1 →	+2.882	+0.211	<.001	<.001	3	14
STOMACH	DKK1 →	+4.171	+0.299	.001	.004	2	14
BLOOD_Lymphoma	WNK2 →	-2.559	-0.356	<.001	<.001	3	12
LUNG_SCLC	TNFRSF12A →	+2.644	+1.093	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010454 vs LGALS1 — LUNG_SCLC

Explore this scatter interactively →