Negative regulation of cell fate commitment

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell fate commitment pathway is significantly associated with the drug response of multiple features, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Telomerase Inhibitor IX, BMS-536924, and HG-5-113-01, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Telomerase Inhibitor IX grouped by Negative regulation of cell fate commitment-low versus -high activity in CNS.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Telomerase Inhibitor IX →	+0.620	+0.174	<.001	.004	3	2
SKIN	BMS-536924 →	-0.695	-0.203	.006	.034	3	1
SKIN	HG-5-113-01 →	-0.387	-0.125	.013	.045	3	1
SKIN	HG-5-88-01 →	-0.605	-0.125	.024	.006	3	1
SKIN	QL-VIII-58 →	-0.896	-0.125	.019	.045	3	1
SKIN	OSU-03012 →	-0.525	-0.200	.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Telomerase Inhibitor IX by Negative regulation of cell fate commitment activity — CNS

Explore this box plot interactively →