Regulation of cell fate commitment

Across TCGA patient cohorts, RNA activity of the Regulation of cell fate commitment pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD38, ACAT1, and TAGAP_S400, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell fate commitment activity versus CD38 in UCEC (Pearson r = -0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD38 →	-0.822	-0.092	<.001	<.001	3	6
PDAC	ACAT1 →	-0.296	-0.034	<.001	<.001	3	5
LSCC	TAGAP_S400 →	-0.467	-0.035	<.001	<.001	3	5
UCEC	TRPM2_S38 →	-0.931	-0.117	<.001	<.001	3	5
PDAC	ARRB1 →	-0.241	-0.037	<.001	<.001	3	5
PDAC	CTSS →	-0.523	-0.047	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010453 vs CD38 — UCEC

Explore this scatter interactively →