Regulation of cell fate commitment

Across TCGA cell cohorts, RNA activity of the Regulation of cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMPO, ORC1, and TFAP4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell fate commitment activity versus TMPO in BLOOD_Leukemia (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMPO →	+1.070	+0.216	<.001	<.001	3	8
SOFT_TISSUE	ORC1 →	+2.145	+0.520	.005	<.001	3	8
BONE	TFAP4 →	+1.792	+0.509	<.001	.008	3	8
BONE	CPSF6 →	+0.634	+0.366	.004	.002	3	7
SOFT_TISSUE	NASP →	+1.470	+0.423	.005	.001	3	7
SOFT_TISSUE	CHAF1A →	+1.791	+0.480	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010453 vs TMPO — BLOOD_Leukemia

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