Response to acidic pH

Across TCGA patient cohorts, RNA activity of the Response to acidic pH pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALDH2, RFC1, and ADAR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to acidic pH activity versus ALDH2 in PDAC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ALDH2 →	+0.534	+0.081	<.001	<.001	3	6
HNSC	RFC1 →	-0.231	-0.056	<.001	<.001	3	5
LSCC	ADAR →	-0.285	-0.064	<.001	<.001	3	5
HNSC	CDC73 →	-0.148	-0.055	.003	.007	3	5
LSCC	GTF3C4 →	-0.349	-0.062	<.001	<.001	3	5
LSCC	IL1RN →	+0.938	+0.071	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010447 vs ALDH2 — PDAC

Explore this scatter interactively →