Response to acidic pH

Across TCGA patient cohorts, RNA activity of the Response to acidic pH pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM3, RAB11FIP5, and CYB5R1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to acidic pH activity versus MCM3 in HNSC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MCM3 →	-0.646	-0.181	.003	.001	3	5
BRCA	RAB11FIP5 →	+0.753	+0.353	<.001	<.001	3	5
HNSC	CYB5R1 →	+0.721	+0.147	<.001	<.001	3	5
LSCC	LINC02577 →	+0.771	+0.225	.001	<.001	3	5
LSCC	ZFPM2-AS1 →	+1.357	+0.246	<.001	.001	3	5
BRCA	STX12 →	+0.453	+0.355	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010447 vs MCM3 — HNSC

Explore this scatter interactively →