Response to acidic pH

Across TCGA cell cohorts, RNA activity of the Response to acidic pH pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CIPC, MICA, and SIRPB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CIPC grouped by Response to acidic pH-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CIPC →	-0.674	-0.886	.002	.001	3	3
STOMACH	MICA →	+1.754	+0.855	.007	.009	3	3
SKIN	SIRPB1 →	+1.411	+0.799	<.001	<.001	3	3
SKIN	GCGR →	+0.025	+0.758	.005	.001	3	3
LUNG_SCLC	PRKCZ →	-2.100	-1.283	.004	<.001	3	3
BLOOD_Lymphoma	GNB5 →	-2.146	-1.922	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CIPC by Response to acidic pH activity — STOMACH

Explore this box plot interactively →