Fatty acid omega-oxidation

Across TCGA patient cohorts, RNA activity of the Fatty acid omega-oxidation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GFPT2, NNMT, and SEC23A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid omega-oxidation activity versus GFPT2 in CCRCC (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GFPT2 →	-0.830	-0.108	<.001	<.001	3	6
OV	NNMT →	-1.099	-0.103	<.001	<.001	3	6
OV	SEC23A →	-0.309	-0.089	.003	.002	3	5
OV	CRTAP →	-0.570	-0.114	<.001	<.001	3	5
OV	EPB41L1 →	+0.484	+0.084	.009	.002	1	7
OV	AP2A1 →	-0.231	-0.084	.003	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010430 vs GFPT2 — CCRCC

Explore this scatter interactively →