Fatty acid omega-oxidation

Across TCGA patient cohorts, RNA activity of the Fatty acid omega-oxidation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCC5, LINC01133, and PCNAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid omega-oxidation activity versus ABCC5 in HNSC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ABCC5 →	+0.921	+0.089	.001	.002	3	4
LSCC	LINC01133 →	+1.496	+0.212	<.001	.002	3	4
HNSC	PCNAP1 →	+0.373	+0.080	.001	<.001	3	3
LUAD	RBL2 →	+0.378	+0.298	<.001	.005	3	3
HNSC	UPK1B →	+2.327	+0.093	<.001	<.001	3	3
LSCC	CNST →	+0.437	+0.208	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010430 vs ABCC5 — HNSC

Explore this scatter interactively →