Membrane invagination

Across TCGA cell cohorts, RNA activity of the Membrane invagination pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B3GALNT2, H3C2, and ZNF7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, B3GALNT2 grouped by Membrane invagination-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	B3GALNT2 →	-1.517	-0.216	<.001	.007	3	5
URINARY_TRACT	H3C2 →	-1.273	-0.497	.002	.004	3	5
LIVER	ZNF7 →	+0.540	+0.274	.003	<.001	3	5
PANCREAS	DDX60 →	+2.701	+0.312	<.001	<.001	3	4
STOMACH	IFI44 →	+2.138	+0.237	.004	.001	3	4
PANCREAS	DDX60L →	+2.081	+0.271	<.001	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

B3GALNT2 by Membrane invagination activity — BLOOD_Lymphoma

Explore this box plot interactively →