Membrane invagination

Across TCGA cell cohorts, RNA activity of the Membrane invagination pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHST7, GNAI2, and TRIO, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane invagination activity versus CHST7 in PANCREAS (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CHST7 →	+1.294	+0.256	.008	.009	3	6
LIVER	GNAI2 →	+1.413	+0.527	<.001	<.001	3	6
LUNG_NSCLC_LUSC	TRIO →	+1.851	+0.277	.003	.003	3	6
LUNG_NSCLC_LUSC	DAPK3 →	+1.315	+0.285	.001	.002	3	6
LUNG_NSCLC_LUSC	CYTH3 →	+1.589	+0.285	<.001	.002	3	6
BLOOD_Leukemia	ATP2B4 →	+1.483	+0.260	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010324 vs CHST7 — PANCREAS

Explore this scatter interactively →