Regulation of hydrogen peroxide metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of hydrogen peroxide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYT17_S110, SELENBP1, and PHYKPL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hydrogen peroxide metabolic process activity versus SYT17_S110 in BRCA (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SYT17_S110 →	+0.964	+0.039	.001	.003	3	4
BRCA	SELENBP1 →	+0.542	+0.038	.002	.001	3	4
CCRCC	PHYKPL →	+0.344	+0.059	.009	.005	3	4
GBM	RXYLT1_S63 →	+0.933	+0.129	.002	.002	3	4
PDAC	ZNF532 →	-0.486	-0.039	.007	.003	3	4
LSCC	ZZZ3_S89 →	+0.769	+0.052	.008	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010310 vs SYT17_S110 — BRCA

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