Regulation of hydrogen peroxide metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of hydrogen peroxide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL2RA, TRAV26-1, and VSIG4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hydrogen peroxide metabolic process activity versus IL2RA in GBM (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IL2RA →	+1.072	+0.097	<.001	<.001	3	5
LSCC	TRAV26-1 →	+0.560	+0.129	<.001	<.001	3	5
GBM	VSIG4 →	+0.985	+0.104	.006	.001	3	5
GBM	LAIR1 →	+0.831	+0.096	.001	.001	3	5
LSCC	TRPV2 →	+0.551	+0.110	<.001	<.001	3	5
GBM	CR1 →	+1.008	+0.106	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010310 vs IL2RA — GBM

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