Response to lead ion

Across TCGA patient cohorts, RNA activity of the Response to lead ion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DAP3, HDGFL3, and LMOD1_S85, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to lead ion activity versus DAP3 in LSCC (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DAP3 →	-0.404	-0.062	<.001	<.001	3	7
UCEC	HDGFL3 →	+0.612	+0.049	.002	.007	3	7
UCEC	LMOD1_S85 →	+1.265	+0.071	<.001	.003	3	7
LSCC	MRPS5 →	-0.361	-0.063	<.001	<.001	3	7
LSCC	MRPS7 →	-0.449	-0.062	<.001	<.001	3	7
LSCC	MRPS9 →	-0.443	-0.057	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010288 vs DAP3 — LSCC

Explore this scatter interactively →