Response to lead ion

Across TCGA cell cohorts, RNA activity of the Response to lead ion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOLGA1, CDK13, and TBC1D12, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to lead ion activity versus GOLGA1 in LUNG_SCLC (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GOLGA1 →	-0.682	-0.672	<.001	.009	3	3
LUNG_SCLC	CDK13 →	-0.422	-0.623	<.001	.001	3	3
BLOOD_Lymphoma	TBC1D12 →	-0.945	-0.460	.001	.006	3	3
BLOOD_Lymphoma	SLPI →	-2.799	-0.668	.002	.003	3	3
BLOOD_Lymphoma	KIAA0232 →	-0.586	-0.620	.005	.005	3	3
BLOOD_Lymphoma	ZBED6 →	-0.796	-0.438	.007	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010288 vs GOLGA1 — LUNG_SCLC

Explore this scatter interactively →