Response to selenium ion

Across TCGA patient cohorts, RNA activity of the Response to selenium ion pathway is significantly associated with the RNA expression of multiple genes, with the LIHC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SELENOM, ODF3B, and LST1, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to selenium ion activity versus SELENOM in LIHC (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	SELENOM →	+1.981	+0.084	<.001	<.001	3	27
SCLC	ODF3B →	+1.491	+0.199	<.001	<.001	3	25
SCLC	LST1 →	+1.767	+0.172	<.001	.001	3	25
SARC	CBX7 →	+1.149	+0.069	<.001	<.001	3	24
SCLC	PSTPIP1 →	+1.004	+0.155	<.001	<.001	3	24
BRCA	ACKR1 →	+1.706	+0.060	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010269 vs SELENOM — LIHC

Explore this scatter interactively →