Response to selenium ion

Across TCGA patient cohorts, RNA activity of the Response to selenium ion pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYBBP1A, RRP1B, and RSU1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to selenium ion activity versus MYBBP1A in COAD (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MYBBP1A →	-0.314	-0.055	.001	<.001	3	10
LUAD	RRP1B →	-0.320	-0.070	<.001	<.001	3	9
COAD	RSU1 →	+0.445	+0.054	<.001	.001	3	9
BRCA	TNS2_S102 →	+0.642	+0.091	<.001	<.001	3	9
LUAD	WDR43 →	-0.297	-0.063	<.001	<.001	3	9
LSCC	EMG1 →	-0.408	-0.071	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010269 vs MYBBP1A — COAD

Explore this scatter interactively →