Response to selenium ion

Across TCGA cell cohorts, RNA activity of the Response to selenium ion pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD9, TBX6, and PTPRB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD9 grouped by Response to selenium ion-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CD9 →	+1.663	+1.060	.004	.007	3	5
UPPER_AERODIGESTIVE_TRACT	TBX6 →	+1.518	+1.824	<.001	<.001	2	5
CNS	PTPRB →	+1.522	+0.926	.003	.001	3	4
BREAST	FAM214A →	+1.312	+1.110	.009	.002	3	4
PANCREAS	BMP4 →	+5.234	+1.951	.003	<.001	3	4
OESOPHAGUS	LMO7 →	+2.615	+1.277	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD9 by Response to selenium ion activity — OVARY

Explore this box plot interactively →