NADH dehydrogenase complex assembly

Across TCGA patient cohorts, RNA activity of the NADH dehydrogenase complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TFB2M, MRTFA_S385, and CDCA5_S33, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, NADH dehydrogenase complex assembly activity versus TFB2M in LUAD (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TFB2M →	+0.452	+0.030	<.001	.001	3	6
LSCC	MRTFA_S385 →	-0.473	-0.042	.004	.001	3	6
LUAD	CDCA5_S33 →	+1.033	+0.047	.004	<.001	3	6
LSCC	SCML2_S511 →	+0.950	+0.040	.001	.006	3	5
LSCC	LRBA_S2496 →	-0.569	-0.040	<.001	.005	3	5
GBM	PHRF1_S814 →	-0.530	-0.040	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010257 vs TFB2M — LUAD

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