NADH dehydrogenase complex assembly

Across TCGA patient cohorts, RNA activity of the NADH dehydrogenase complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VGLL3, DCN, and LRCH1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, NADH dehydrogenase complex assembly activity versus VGLL3 in BRCA (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VGLL3 →	-0.671	-0.216	.001	.001	3	6
CCRCC	DCN →	-1.315	-0.127	.002	.005	3	5
BRCA	LRCH1 →	-0.542	-0.196	<.001	.005	3	5
UCEC	CCDC80 →	-0.953	-0.188	.003	.006	3	5
CCRCC	DDR2 →	-0.578	-0.112	<.001	.003	3	5
GBM	RBMS1 →	-0.688	-0.217	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010257 vs VGLL3 — BRCA

Explore this scatter interactively →