NADH dehydrogenase complex assembly

Across TCGA cell cohorts, RNA activity of the NADH dehydrogenase complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSB, CDCA4, and ZNF318, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTSB grouped by NADH dehydrogenase complex assembly-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CTSB →	-1.628	-0.244	.001	.001	3	5
LUNG_SCLC	CDCA4 →	-0.800	-0.619	.005	.009	3	4
OESOPHAGUS	ZNF318 →	-0.734	-0.178	.001	.009	3	4
BREAST	JTB →	+1.000	+0.383	<.001	<.001	3	4
BREAST	DPYD →	-1.265	-0.221	.009	.005	3	4
BREAST	MAP4 →	-0.594	-0.238	.009	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTSB by NADH dehydrogenase complex assembly activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →