Vascular transport

Across TCGA patient cohorts, RNA activity of the Vascular transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_S368, GGT5, and OLFML1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular transport activity versus RFC1_S368 in LSCC (Pearson r = -0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC1_S368 →	-0.587	-0.031	<.001	<.001	3	10
OV	GGT5 →	+0.616	+0.027	<.001	.007	3	9
UCEC	OLFML1 →	+1.174	+0.057	<.001	<.001	3	9
OV	RPL5 →	-0.214	-0.030	<.001	.001	3	9
LSCC	WDR36 →	-0.289	-0.038	<.001	<.001	3	9
UCEC	CDK1 →	-0.714	-0.057	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010232 vs RFC1_S368 — LSCC

Explore this scatter interactively →