Vascular transport

Across TCGA patient cohorts, RNA activity of the Vascular transport pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC4A4, RUNX2, and LDHAL6EP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular transport activity versus SLC4A4 in PDAC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SLC4A4 →	+1.217	+1.080	<.001	<.001	3	7
PDAC	RUNX2 →	-0.559	-1.092	<.001	<.001	3	5
PDAC	LDHAL6EP →	+1.009	+1.104	<.001	<.001	3	4
HNSC	FMNL3 →	-0.457	-0.608	.005	.008	3	4
HNSC	HNRNPA1P29 →	-0.697	-0.447	.003	.003	3	4
HNSC	KLHL30-AS1 →	-0.259	-0.581	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010232 vs SLC4A4 — PDAC

Explore this scatter interactively →