Vascular transport

Across TCGA cell cohorts, RNA activity of the Vascular transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLSCR4, MTURN, and EML6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLSCR4 grouped by Vascular transport-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PLSCR4 →	+1.249	+0.887	.007	.009	3	4
PANCREAS	MTURN →	-1.562	-1.029	.001	.006	3	4
SOFT_TISSUE	EML6 →	-0.853	-0.739	.004	.009	3	3
SOFT_TISSUE	YJEFN3 →	-1.204	-0.785	<.001	.005	3	3
LUNG_NSCLC_LUSC	ZNF337 →	-1.076	-1.208	.005	.007	3	3
URINARY_TRACT	DYM →	-0.758	-1.425	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLSCR4 by Vascular transport activity — LUNG_SCLC

Explore this box plot interactively →