Response to lithium ion

Across TCGA cell cohorts, RNA activity of the Response to lithium ion pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IMPA2, FRAT2, and CDKN1B, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to lithium ion activity versus IMPA2 in KIDNEY (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	IMPA2 →	+2.746	+0.326	<.001	<.001	3	15
LUNG_NSCLC_LUSC	FRAT2 →	+1.137	+0.230	.003	.009	3	10
BREAST	CDKN1B →	+1.347	+0.176	<.001	<.001	3	10
URINARY_TRACT	ADAMTS6 →	-2.491	-0.232	<.001	<.001	3	9
LUNG_SCLC	MYLIP →	+1.543	+0.228	.001	.004	3	9
OVARY	FAAH →	+1.979	+0.233	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010226 vs IMPA2 — KIDNEY

Explore this scatter interactively →