Response to UV-C

Across TCGA patient cohorts, RNA activity of the Response to UV-C pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CTNNA1, CEP170, and GBP5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to UV-C activity versus CTNNA1 in HNSC (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CTNNA1 →	-0.271	-0.057	<.001	.007	3	7
COAD	CEP170 →	+0.314	+0.020	<.001	.006	3	6
LUAD	GBP5 →	+0.728	+0.054	<.001	<.001	3	6
COAD	MCCC2 →	-0.440	-0.023	<.001	<.001	3	6
LSCC	ALDH6A1 →	-0.256	-0.036	.007	.004	3	6
GBM	ITGA5 →	+0.362	+0.028	.002	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010225 vs CTNNA1 — HNSC

Explore this scatter interactively →