Response to UV-C

Across TCGA patient cohorts, RNA activity of the Response to UV-C pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEZ6L, MYL3, and ATP1A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to UV-C activity versus SEZ6L in GBM (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEZ6L →	-1.577	-0.735	.001	.001	3	4
LUAD	MYL3 →	-0.273	-0.130	<.001	.003	3	4
GBM	ATP1A2 →	-1.605	-0.799	<.001	<.001	3	4
GBM	PNMA3 →	-0.861	-0.653	.001	.003	3	4
GBM	LINC02669 →	-0.469	-1.207	<.001	<.001	3	3
GBM	BSN-AS1 →	-0.364	-0.757	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010225 vs SEZ6L — GBM

Explore this scatter interactively →