Response to UV-C

Across TCGA cell cohorts, RNA activity of the Response to UV-C pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MDM2, CDKN1A, and BBC3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MDM2 grouped by Response to UV-C-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MDM2 →	+1.015	+0.446	.001	.006	3	6
STOMACH	CDKN1A →	+2.282	+0.470	<.001	.008	3	5
LARGE_INTESTINE	BBC3 →	+0.902	+0.698	.002	.002	3	4
OESOPHAGUS	ZXDA →	-0.835	-1.792	.002	<.001	3	4
LARGE_INTESTINE	RPS27L →	+1.007	+0.613	<.001	.005	2	5
BLOOD_Lymphoma	AK4 →	-2.316	-1.677	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MDM2 by Response to UV-C activity — LARGE_INTESTINE

Explore this box plot interactively →