Response to UV-B

Across TCGA patient cohorts, RNA activity of the Response to UV-B pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TIMP2, SRP68, and PLCD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to UV-B activity versus TIMP2 in BRCA (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TIMP2 →	+0.676	+0.047	<.001	<.001	3	7
BRCA	SRP68 →	-0.243	-0.036	<.001	.002	3	7
BRCA	PLCD1 →	+0.391	+0.034	<.001	<.001	3	7
COAD	PTCD3 →	-0.272	-0.027	<.001	<.001	3	6
BRCA	SEPTIN2 →	+0.230	+0.038	<.001	<.001	3	6
BRCA	UTRN →	+0.205	+0.036	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010224 vs TIMP2 — BRCA

Explore this scatter interactively →