Response to UV-B

Across TCGA patient cohorts, RNA activity of the Response to UV-B pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCYT1B, GDF11, and SLAIN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to UV-B activity versus PCYT1B in GBM (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PCYT1B →	-0.910	-0.315	<.001	<.001	3	5
GBM	GDF11 →	-0.455	-0.239	.001	<.001	3	5
HNSC	SLAIN1 →	-0.733	-0.167	<.001	.005	3	4
LSCC	RAB6B →	-1.231	-0.204	.002	<.001	2	5
LSCC	TSPAN33 →	-0.540	-0.199	<.001	<.001	3	4
LSCC	ZNF233 →	-0.639	-0.208	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010224 vs PCYT1B — GBM

Explore this scatter interactively →