Response to UV-B

Across TCGA cell cohorts, RNA activity of the Response to UV-B pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS16, OLFML2A, and RNF157, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to UV-B activity versus ADAMTS16 in LARGE_INTESTINE (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADAMTS16 →	-0.579	-0.691	.005	.003	3	3
LARGE_INTESTINE	OLFML2A →	-0.692	-0.853	.003	<.001	3	3
URINARY_TRACT	RNF157 →	-2.290	-0.348	.003	.004	3	3
LIVER	PURB →	-0.730	-1.307	.007	.002	3	3
LIVER	TMEM17 →	-0.728	-1.251	.005	.005	3	3
LIVER	PITPNM3 →	-2.085	-1.731	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010224 vs ADAMTS16 — LARGE_INTESTINE

Explore this scatter interactively →