Response to ionizing radiation

Across TCGA patient cohorts, RNA activity of the Response to ionizing radiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LDLR, FOS, and TMEM220-AS1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ionizing radiation activity versus LDLR in BRCA (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LDLR →	+1.378	+0.209	<.001	.007	3	2
BRCA	FOS →	+2.397	+0.209	.005	.007	3	2
BRCA	TMEM220-AS1 →	-0.403	-0.286	<.001	.002	3	2
BRCA	ABCA7 →	+0.974	+0.208	<.001	.007	3	2
COAD	SSBP4 →	+0.647	+0.196	<.001	<.001	3	2
COAD	SSH3 →	+0.426	+0.160	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010212 vs LDLR — BRCA

Explore this scatter interactively →