Response to ionizing radiation

Across TCGA cell cohorts, RNA activity of the Response to ionizing radiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIPA1L3, NTNG1, and ABT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SIPA1L3 grouped by Response to ionizing radiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SIPA1L3 →	+0.800	+0.106	.003	.004	3	4
BONE	NTNG1 →	-2.038	-0.192	.006	.003	3	3
LUNG_SCLC	ABT1 →	+0.745	+0.220	.003	.001	3	3
LUNG_SCLC	PPP1CA →	+1.068	+0.216	<.001	.001	3	3
LUNG_SCLC	GK5 →	-0.806	-0.194	<.001	.003	3	3
LUNG_SCLC	PUS1 →	+0.760	+0.177	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SIPA1L3 by Response to ionizing radiation activity — BREAST

Explore this box plot interactively →