Response to ionizing radiation

Across TCGA cell cohorts, RNA activity of the Response to ionizing radiation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EI24, TRIM59, and IKBIP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ionizing radiation activity versus EI24 in SOFT_TISSUE (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	EI24 →	+0.735	+0.160	.003	.003	3	5
BONE	TRIM59 →	+1.726	+0.191	.008	<.001	3	4
OVARY	IKBIP →	+1.731	+0.196	.003	<.001	3	4
SKIN	CIAO2A →	-0.716	-0.175	.001	.001	3	4
STOMACH	COA4 →	+0.682	+0.167	.009	<.001	2	5
URINARY_TRACT	LOXL2 →	+4.010	+0.258	.008	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010212 vs EI24 — SOFT_TISSUE

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